Description
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AHK-Cu — Synthetic Copper Tripeptide For Hair Research
AHK-Cu (Alanine-Histidine-Lysine copper complex) is a synthetic copper-binding tripeptide designed specifically for hair follicle and dermal biology research. While structurally related to the naturally occurring GHK-Cu, AHK-Cu is an entirely synthetic peptide with distinct receptor binding characteristics and enhanced specificity for dermal papilla cell activation and hair growth cycle modulation.
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Mechanism Of Action
AHK-Cu stimulates dermal papilla cell (DPC) proliferation and promotes the transition from telogen (resting phase) to anagen (growth phase) in hair follicle cycling. Research demonstrates its ability to upregulate VEGF expression in dermal papilla cells, enhance ECM signaling through integrin pathways, and modulate Wnt/β-catenin signaling — a critical pathway in hair follicle morphogenesis and regeneration. The copper ion component serves as a cofactor for lysyl oxidase and other matrix-remodeling enzymes.





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